Postpartum hemorrhage that leads to blood transfusion is the leading cause of severe maternal morbidity ... show more

Background: Postpartum hemorrhage that leads to blood transfusion is the leading cause of severe maternal morbidity in the US; Rate of postpartum hemorrhage increased 26% between 1994 and 2006 (primarily due to increased atony); Accounts for slightly more than 10% of maternal mortalities; Mortality rates from PPH are decreasing (currently approximately 1.7 deaths per 100,000 live births); By the time a patient has tachycardia/hypotension, significant blood loss (up to 25% of total blood volume) has already occurred. show less